Adaptive Human CDKAL1 Variants Underlie Hormonal Response Variations at the Enteroinsular Axis
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چکیده
منابع مشابه
Adaptive Human CDKAL1 Variants Underlie Hormonal Response Variations at the Enteroinsular Axis
Recent analyses have identified positively selected loci that explain differences in immune responses, body forms, and adaptations to extreme climates, but variants that describe adaptations in energy-balance regulation remain underexplored. To identify variants that confer adaptations in energy-balance regulation, we explored the evolutionary history and functional associations of candidate va...
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Rediscovery of the role of the gastrointestinal tract in the control of carbohydrate metabolism and, as we now know, fat and protein metabolism, was made independently in London by two groups of workers (Dupre, 1964a; McIntyre et al., 1964). The major credit undoubtedly belongs to McIntyre and his colleagues (1964, 1965) who, by the simplest of methods, namely comparing the glycaemic and insuli...
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OBJECTIVE Ghrelin, a potent stimulator of GH secretion, also acts as an orexigenic hormone. Plasma ghrelin levels rise before meals with postprandial reduction, suggesting that circulating levels of enteroinsular hormones might influence ghrelin secretion. AIM The aim of this study was to evaluate the effects of ghrelin on enteroinsular hormones in healthy men. DESIGN Three tests were perfo...
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Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site. Until recently, hyperinsulinemia has been considered a counterregulatory response to insulin resistance (IR), but there is growing evidence to support a gastrointestinal etio...
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Response time (RT) is an oft-reported behavioral measure in psychological and neurocognitive experiments, but the high level of observed trial-to-trial variability in this measure has often limited its usefulness. Here, we combine computational modeling and psychophysics to examine the hypothesis that fluctuations in this noisy measure reflect dynamic computations in human statistical learning ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0105410